Women and Cancer
Women and Cancer
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The War Room
The War Room Therapeutic Advances and Drugs in the News

The latest developments in treatment and research play a central role in each issue of Women&Cancer. We want our readers to know what therapies are available and what drugs may be an option in the future so that they can make informed, empowered decisions about their own health and the health of their loved ones.

We feel that the in-depth articles describing advances in treatment and the current research news are best illustrated by real-life stories of women who have felt the impact of a cancer diagnosis themselves, so throughout the section we take care to share personal stories of survivorship and advocacy. The women whose journeys are highlighted on these pages give real meaning to the advances that are being made in cancer treatment today, and “The War Room” is brought to life by their stories.

Spring 2008 Articles
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Cover Up!
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Simple Screening for a Deadly Disease
Thanks to recent media campaigns, at this point most of us have heard the message that spending time in the midday sun without protection is not a good idea. At some point in our lives, however, the majority of us have broken the rules, either intentionally going after that deadly tan or at the very least spending brief periods outside while forgetting to protect ourselves from the sun.
Treatment of Nonmelanoma Skin Cancer
Each year in the United States, more than one million people are diagnosed with basal cell or squamous cell skin cancers.
More Than Skin Deep
When Skin Cancer Requires Surgery and Reconstruction
The Skin Cancer Foundation
When Dr. Perry Robins founded the Skin Cancer Foundation in 1979, the fledgling advocacy organization faced major obstacles
Getting Your Head Around Brain Cancer
Understanding this complex disease and its treatment options
Brain Tumor Advocacy Groups
"There's not a typical brain tumor survivor," says Sarah Gupta, LICSW
Advances In Breast Cancer Treatment
A Report from the 2007 Annual San Antonio Breast Cancer Symposium
A Special Kind of Sisterhood
A group of HER2-positive survivors in Bakersfield, California, come together to empower one another and inform the public about their disease.
The War Room News
• Adjuvant Taxotere Improves Breast Cancer Survival
• Erbitux Improves Survival in Colorectal Cancer
• Tasigna Approved for Chronic
Additional Articles
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Hope Shines Brightly for Ovarian Cancer Survivors
By Krishnansu S. Tewari, MD, FACOG, FACS
Ovarian Cancer Advocacy
Poems for Hattie
In the face of the sometimes-unspeakable emotions surrounding a cancer diagnosis, two friends find the words of poets to say what they sometimes cannot, sending verse across the Atlantic and coming to terms with illness, love, and the meaning of their valuable friendship.
Bare Bones Basics
Many women don’t think about bone loss as a major health concern, but learning about this issue—and ways to prevent it—may be more important than we realize.
Bone-Building Recipes
• Italian Sardine Spread
• Ginger Yogurt with Berries
• Spanish Collard Greens
War Room News
• Addition of Erbitux to Chemotherapy Improves Survival in Advanced Non–Small Cell Lung Cancer
• Further Results Show Improved Survival with Picoplatin for Small Cell Lung Cancer
• Further Evidence That Nexavar Improves Liver Cancer Survival Among Different Ethnic Groups
• Evista Approved for Prevention of Breast Cancer
Knowledge is Power
Jaclyn Smith’s diagnosis of breast cancer taught her the value of becoming educated about her health and the power of being lifted by love.
Advances in Breast Cancer Treatment
A Report from the 2007 Annual Meeting of the American Society of Clinical Oncology
Stepping Up Early Detection
Can magnetic resonance imaging improve early detection of breast cancer?
Special Report: Metastatic Breast Cancer
Patients diagnosed with Stage IV or metastatic breast cancers have disease that has spread from the affected breast to one or more distant sites in the body.
Sharsheret
For young Jewish women with breast cancer, common cultural traditions and a sisterhood of support create a welcome home after diagnosis.
Inflammatory Breast Cancer: What You don’t know Can Hurt You
An infrequent but aggressive type of breast cancer requires immediate treatment, but many women have never heard of it.
Inflammatory Breast Cancer Advocacy
Although breast cancer is one of the most widely covered cancers in the media and is represented by innumerable advocacy groups, inflammatory breast cancer (IBC) hasn’t historically received adequate attention, leaving those facing the disease with insufficient resources and avenues of support as they battle a breast cancer with characteristics and treatment protocols that tend to differ significantly from those of other disease types.
It's in the Genes News
• Oncotype DX Influences Breast Cancer Treatment Choices
• Aspirin Protects Against Subset of Colorectal Cancers
• Further Evidence Suggesting Survival Associated with Surgeon Experience in Ovarian Cancer
• Switching from Tamoxifen to Aromatase Inhibitor Improves Survival in Early Breast Cancer
• Femara Reduces Risk of Early Recurrence of Breast Cancer
Leukemia 101
A Basic Guide to Understanding Leukemia
Gleevec and the Chronic Myeloid Leukemia Revolution
How one targeted therapy gives new meaning to “living with cancer”
From Research to Reality
An Interview with Dr. Brian Druker
Cancer’s Glamour Girl
Down-to-earth and down-to-business when it comes to cancer advocacy, Erin Zammett Ruddy discusses her very public journey with chronic myeloid leukemia and why she continues to share her story.
Connecting for a Cure
The Leukemia & Lymphoma Society Is United for Support, Research, and, Ultimately, a Cure
Lifeline
Umbilical cord blood stem cells save lives and provide an important resource for medical research
War Room News
• MRI Screening for Breast Cancer
• Tykerb Approved for Advanced Breast Cancer
• Oncotype DX Effectively Guides Breast Cancer Treatment
• Clinical Trial Evaluating Myocet for Breast Cancer Now Enrolling Patients
• HPV Vaccine Recommended, but Many Unaware of Its Importance
Striking Blows Against Bladder Cancer
Learning about this often-overlooked cancer may save your life.
The Bladder Cancer Web Cafe
Connection and Information The Bladder Cancer WebCafé
Stop Skin Cancer: Before It's More Than Skin Deep
Skin cancer is the most commonly diagnosed cancer in the U.S., with more than one million new cases each year. Although many cases are curable, others are not. Prevention and early detection are the keys to good outcomes.
The Melanoma Research Foundation
One dedicated patient’s dream becomes a reality, as melanoma education, research, and advocacy become the passionate focus for a committed group of survivors, families, and friends.
Bioidentical or Synthetic: New Choices in Hormone Replacement Therapy
New choices in hormone replacement therapy are raising questions about what is safe, what is effective, and what is “natural.”
War Room News
• Femara Improves Cancer-free Survival in Early Breast Cancer
• Six Cycles of Rituxan-CHOP-14 Confirmed as Standard of Care for Elderly with Diffuse Large B-cell Lymphoma
• Herceptin Improves Survival in HER2-positive Early Breast Cancer
• Follow-up Data on Dose-dense Chemotherapy Confirm Benefit in Early Breast Cancer
• Prevalence of HPV in the U.S. Greater than Previously Thought
Weighing the Risks
The issue of body weight is a loaded one. For many of us, it consumes far too much of our energy and attention. In recent years the media have given a lot of attention to the psychological effects that weight and body image issues can have, particularly on women. But despite the unhealthy effect that too much emphasis on an ideal body can have, some attention to body weight—and the associated health issues—is warranted. An unhealthy weight, whether it’s too little weight or too much, can in fact have dramatic effects on health. In addition to increasing the risk of chronic conditions such as diabetes and heart disease, there is evidence that obesity increases the risk of developing certain types of cancer and can decrease survival with cancer.
C3: Colorectal Cancer Coalition
Kate Murphy, director of research communication at the C3: Colorectal Cancer Coalition, was first diagnosed with colon cancer 23 years ago when she was 40. Since then she has had ovarian cancer, breast cancer, and a second colon cancer, but for the past 12 years she has been cancer-free. Kate knows the struggles of the patients and their loved ones who come to the advocacy organization, looking for information and support, and she reflects the organization’s passion as she describes its goals for the visitors to its online community at www.fightcolorectalcancer.org.
Women Have Colons Too
Fewer than 50 percent of women undergo the recommended screening for colorectal cancer in the United States,1 and yet this disease takes the lives of more women each year than ovarian and cervical cancers combined.2 In fact, colorectal cancer is the second-leading cause of cancer death in the United States.3 So why are more women not getting screened? Part of the answer may lie in the misconception that colorectal cancer is a disease that affects only men or in the lack of information about screening guidelines and risk factors for women.
In Their Own Words
Colorectal Cancer Survivor Stories
Highlights from the San Antonio Breast Cancer Symposium
• Decline in Postmenopausal Hormone Use May Explain Drop in Breast Cancer Rate
• Abraxane® Improves Response Rates and Progression-free Survival—with Fewer Side Effects than Taxotere®—in Metastatic Breast Cancer
• Herceptin® and Arimidex® Improves Outcomes in Advanced Breast Cancer
The Verdict Is In: Screening Saves Lives
Breast cancer is diagnosed in more than 200,000 women every year in the United States alone. If detected and treated early, prior to the spread of cancer from the breast to distant sites in the body, cure rates remain high; as the cancer progresses and spreads, long-term survival rates fall dramatically. Therefore it seems only logical that early detection through screening measures—such as mammography (an X-ray of the breast)—will ultimately result in improved survival for women diagnosed with breast cancer.
A Good Prognosis Gets Better: Advances in the Treatment of Early-stage Breast Cancer
Though a diagnosis of breast cancer will always be a shock, women diagnosed with early-stage breast cancer can be reassured by the fact that because the cancer was caught at an early stage, their diagnosis has been delivered when treatment has the best chance of success. Furthermore, recent advances in the treatment of early-stage breast cancer promise greater improvement in patient outcomes.
Gratitude and Grace: The Sheryl Crow Interview
Maybe she’s just a little worn out from her tour schedule—I’ve caught her on a rare day off during month 4 of her Wildflower tour—but a few minutes of conversation reveal the real story, which is much more profound. Her quiet, unhurried, and thoughtful responses reflect someone in touch with the value of her life these days. Her voice, so powerful and beautiful in the music that has earned her nine Grammys and has sold more than 30 million albums, is calm and reflective. Her answers—softened by a slight southern lilt—give me a glimpse of a woman who in recent months has been pushed to come to know herself more intimately than ever before and, having been tested, has found the peace that comes from knowing your own strength and recognizing your own value.
Young Survival Coalition
The Young Survival Coalition (YSC) wants young women with breast cancer to feel empowered. “You are too young for breast cancer is not a diagnosis,” says Michele Przypyszny, YSC’s CEO. “And if you feel your doctor is not addressing your concerns thoroughly, find one who will.” Delivering young women the tools they need to take their breast health into their own hands and recognize that they have the power to advocate for their own well-being is one goal of the organization—the only international, nonprofit group dedicated to the concerns and the issues unique to young women with breast cancer.
Environmental Estrogens
Many variables within a woman’s body contribute to her development of breast cancer; so too, we’re learning, do factors within her environment. We’re zeroing in on the risk factors within the body as research tells us that—among other things—hereditary genes can contribute to the risk of developing the disease. The impact of various environmental factors is still being evaluated, but studies aimed at determining which chemicals and products might contribute to the development of breast cancer are offering clues as to how the environment fits into the cancer-risk puzzle.
Reconstructing Hope: Breast Reconstruction from the Plastic Surgeon’s Point of View
Many of my patients are coping with breast cancer—newly diagnosed, undergoing treatment, or presenting as long-term survivors. Conceptually, everyone understands that there is nothing more important than treating and hopefully curing their cancer and that the side effects are worth bearing for the end result. In actuality, however, not all patients can easily face the reality that some of these important treatments—surgery and radiation included—may leave a breast changed forever: absent, scarred, smaller, or misshapen. They may be facing a new reality when they look at one or both of their breasts.
A Survivor’s Story: For Babies and Balance
For Katherine Jensen, the decision to reconstruct her breasts after cancer treatment was motivated by the many babies who snuggle against her chest. “I am a certified nurse midwife,” Katherine says, “and the thought of a baby snuggling up to my ribcage did not seem right. For me it was not about how I looked in clothes or to anyone else but about how the babies would feel and how I would feel holding them.” Katherine lives in Portland, Oregon, and was diagnosed in April 2001 with Stage IIB invasive ductal carcinoma. In an effort to remove the cancer, doctors performed two lumpectomies on Katherine’s right breast but were unable to get clear margins. She had three of 20 positive nodes and began chemotherapy.
What’s on the Horizon? Microsurgery Options
A cancer diagnosis and all of its related emotions can be an overwhelming experience for many women. The thought of a mastectomy added to the mix can be even more frightening. Loss of a breast might provoke feelings of incompleteness or disfigurement or contribute to a loss of sexuality. But women facing this experience today should know that reconstruction of the breast can be a positive experience that can help restore self-image and self-esteem.
Cancer & Race in America
Cancer remains a significant health problem in African American, Hispanic, and American Indian people despite advances in screening, prevention, and treatment. Women from these populations continue to present with later stages of breast, cervical, and colorectal cancer at diagnosis and have lower survival when compared with White women.
The War Room News
• "Gardasil® Also Likely to Prevent Most Vaginal and Vulvar Cancers"
• "Celebrex® Reduces Pre-cancerous Colorectal Tumors but Increases Cardiovascular Risks"
What Every Woman Should Know About Cancer Screening
Over the past several decades, long-term cancer survival rates have been on the rise. These improved outcomes are largely credited to screening measures for certain types of cancers. In general, cancer that can be detected and treated in its earliest stages, prior to any spread—and often prior to any symptoms—is associated with dramatically higher long-term survival than cancer that is treated once it has spread from its site of origin.2 As a result, screening for common types of cancers gives patients the best chances for early detection and effective treatment, which allow for the best chances for survival. People at a high risk of developing a specific type of cancer may also undergo frequent screening for that type.
Breaking News from ASCO
• "Chemotherapy Benefits Elderly Patients with Non–Small Cell Lung Cancer"
• "Erbitux plus Induction Chemotherapy Results in 100 Percent Response Rate for Head and Neck Cancer"
• "Additional Evidence of Abraxane Activity in Advanced Non–Small Cell Lung Cancer"
• "Vidaza Reduces Need for Transfusions in Myelodysplastic Syndromes"
• "Tykerb Halts Cancer Progression in Advanced Breast Cancer"
• "Panitumumab-targeted Therapy Provides Anticancer Activity in Patients with Advanced Colorectal Cancer"
• "GVAX Achieves Significant Anticancer Responses in CML"
• "Study Continues to Suggest Benefit of Nexavar in the Treatment of Advanced Kidney Cancer"
• "Addition of Erbitux to XELOX Reduces Cancer Progression as First-line Therapy in Metastatic Colorectal Cancer"
Cervical Cancer: From Viruses to Vaccines
For women in the United States, a Papanicolaou (Pap) test has become a standard part of their annual gynecologic exam. Also known as a Pap smear, the test, which was first made public in 1943 when George Papanicolaou and Herbert Traut published their landmark paper Diagnosis of Uterine Cancer by the Vaginal Smear,1 revolutionized the field of cervical cancer prevention by allowing physicians to detect and treat cervical cancer in its earliest stages. In countries with the resources for screening and treatment, widespread cervical cancer screening programs continue to lead to dramatic declines in deaths from this disease.
Breaking the Silence: Telling the Story of Women and Lung Cancer
Though recurrent shoulder pain sent 70-year-old Mary* to see her doctor last year, the Oregon resident never thought she would have reason to be thankful for her arthritis and that doctor’s visit. An X-ray of her shoulder revealed a mass in her lung. Subsequent surgery removed a quarter-sized cancer from the upper lobe of her right lung. Her reaction to the diagnosis: complete surprise. “Colon cancer wouldn’t have surprised me,” she says, but the lung cancer was a shock.
Hear Me Roar: The Changing Face of Lung Cancer
Holly Springs, Georgia, resident Jacqueline Patrick was in a car accident on the day she was diagnosed with lung cancer. Ironically, it was the head-on collision that saved her life. After the moment of impact, Jacqueline immediately had trouble breathing and called 9-1-1. Though it was later revealed that she was not actually hurt in the crash, as a result of the accident she was taken to the hospital for X-rays and scans. It was during these tests that a tumor the size of an orange was discovered in her lower right lobe.
A Legacy of Compassion and Commitment: The Joan Scarangello Foundation to Conquer Lung Cancer
Roxanne Donovan does not hesitate when asked to describe her sister-in-law and closest friend, Joan Scarangello McNeive: “Joan was absolutely magnificent. She was passionately alive and present. She walked through the world with her shoulders back and her head held high. She reveled in the lives of her wide circle of family and friends.”
National Lung Cancer Partnership
Lung cancer strikes down more American women each year than any other cancer. But ask most women if they’ve every worn a ribbon for lung cancer or participated in a walk to show their support for lung cancer survivors, and chances are they probably have not. The National Lung Cancer Partnership (NLCP, formerly Women Against Lung Cancer) is working hard to change that.
Lung Cancer Screening: What's the Standard?
Despite the alarming numbers of women impacted by lung cancer each year in the U.S., there is no consensus today among medical professionals on the benefits of routine screening. This, despite the fact that lung cancer commonly goes undetected until it has progressed to a point that it can no longer be cured. For this reason, the development of accurate screening methods to detect lung cancer early, before symptoms arise, is critical.
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